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Chemical reagents and products designed to conduct fluorescent in situ hybridizations, a technique used to bind fluorescent probes to specific nucleic acids. Products may be available as kits.
Empire Genomics' NECTIN4/CON1 vB FISH Probe is a specialized tool designed for detecting NECTIN4 gene copy number variations in scientific research. This probe incorporates an internal control to enhance accuracy and reliability while being pre-labeled with distinct Orange and Green fluorophores for clear signal differentiation. It is supplied as a concentrate, offering 20 tests per kit.
Target gene: NECTIN4
Application: Copy number variation detection
Internal control: Yes
Fluorescent labels: Orange-dUTP, Green-dUTP
Orange label excitation: 552 nm
Orange label emission: 576 nm
Green label excitation: 491 nm
Green label emission: 516 nm
Tests per kit: 20 tests
Probe volume per test: 2 μL
Product type: FISH probe
Regulatory status: Research Use Only (RUO)
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
The highly leukemogenic avian retrovirus E26 contains two oncogenes v-Myb and v-Ets which are expressed together as a fusion protein The cellular homolog of v-Myb designated c-Myb encodes a transcription factor Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel leads to activation of its ability to transform hemopoietic cells c-Myb is expressed preferentially but not exclusively in immature hemopoietic cells and its expression decreases as cells differentiate Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
FOSL1 degrader 1 is a T-5224-based PROTAC designed to selectively degrade FOSL1 (AP-1), suppress cancer-stemness gene expression, and inhibit tumor growth in preclinical head and neck squamous cell carcinoma (HNSCC) models. It shows substantially increased potency compared with the parent inhibitor and is supplied as a solid with high purity for research use.
Targets FOSL1 (AP-1) for proteasomal degradation
Suppresses cancer stemness gene expression in HNSCC models
Eliminates cancer stem cells and inhibits tumor growth in preclinical studies
Demonstrates approximately 30-100x increased potency over the parent inhibitor
High purity suitable for preclinical research
DMSO soluble at ≥100 mg/mL for straightforward formulation
Available in small research quantities for laboratory experiments
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More